I was talking to a couple of RV transport drivers who came to our store. They were telling me that overdrive units can make a hellava difference in fuel mileage. One of the guys had a Cummins 12v with a GV and claimed a pretty tall mpg figure that I had to take a "Yea, right" attitude about. I think he was saying something like 18-20 towing mpg with a monster-sized 5th wheel RV.
One thing I remember them telling me, was that one of the units, GV or US Gear, would not hold up to the use of an exhaust brake. I don't recall which it was though.