Go with singles, better fuel mileage, lots easier on the hpop as rooster said, and the singles do make more power.
That's exactly what Jody @ DP-Tuner told me also.
If you currently have split shots and go with singles, you will need some computer tuning also. Since I have an early 99, I went with a new PCM from DP-Tuner previously. I did have an XLE8 w/ a Banks chip. I was never happy with the way the tranny ran with that setup. I went to an updated 99.5 PCM with a PMT-1 Econo tune and the change was unbelievable.
When I had to replace injectors, I went with Stage I single shots for the same reasons listed by Twildman and DP-Tuner. I have been having some rough idle glitches associated with PCM tuning. I think we've been making headway on figuring out a solution. I got a chip from Bean's which idles smooth as silk. But I think I like the over pull and power of the PCM tune better, if I could just get it to idle like the chip I'd be