f250 short box...i think it will squat considerably as the rear set of springs are not the same on the 350 long box. most 250s'''short boxes are built for ride over spring stiffness, unless you get the higher gvwr, which pushes you to a 350 .
back in the day my 92 f250 4x4 supercab long box....it took a few gorillas to even phase the load height
now i come from a f350 dually tow boss and it squatted a bit with 2700 lbs of pin weight over the rear axle, and occasionally would touch the over loads
i would get the actual weight of truck empty,
then with your load and see the real world weight. and compare that to the towing and cargo weight guide for your model to find out what the real world cargo capacity is rated for your truck.