Modify the oil? Or modify your truck. As mentioned, both have their sets of pros and cons. The biggest deciding factor would be driving habits. If most of your trips are less than 20 miles, then go biodiesel. WVO works best if you're at full operating temperature. So to get your WVO up to the necessary 150F minimum temp, we're talking at least 5-6 miles of highway driving before switching the valve over to WVO. Then of course there's the shutdown period to purge system with diesel. Many of the 'WVO horror' stories you hear about have to do with running improper temperatures. Cold WVO will not spray, or atomize properly and that's when you get incomplete combustion, coked rings, glazed cylinder walls, and diluted crankcase oil.
Most of my trips are less than 20 miles so biodiesel is my choice. But consider that your equipment will occupy about 1/2 car length of space, and that this is a pretty involved hobby. I love making it and have a pretty good system for it making 50-100 gal/month.
Lastly, make sure you have secured your wvo source before you commit to anything, either way. Without it, you're dead in the water.