Over the last 15 years since the Superduty was introduced in mid 1998 as a 1999 model year, I've seen several air suspension companies come and go out of business. The companies that spend more talking about the benefits of air suspension in general, rather than the specific implementation of their air suspension system in particular, tend to be the ones that disappear first. The "Air Ax" company comes to mind. Gone in 60 seconds (well, maybe about a year).
BJS hinted at a very real concern... axle location laterally. This is critical for vehicle stability under fully loaded stress. While the initial installation may work good for a while, if the lateral location of that axle does fail prematurely, the results are catastrophic.
I never heard of Autoflex before, but upon the OP's question, I searched their website. What I was looking for was how the axle would be located laterally, and how the axle wrap on acceleration from a standing start would be controlled. I did not find what appeared to me to be sufficient hardware to control either axle wrap or axle yaw. I also looked for installation instructions, which I wasn't able to find (not to say they are not available, I just couldn't find them).
On the other hand, I have heard of Reyco Granning, Hendrickson, Silent Drive, Ridewell, Morryde, Link, and Kelderman. These companies are not new, and they have been manufacturing substitution suspension systems for trucks for 20 years or longer. They each have clearly visible mechanisms for controlling lateral and angular movement of the axle. They each spend time talking about how their type of suspension replacement is implemented, not just how much nicer their suspension is over leaf springs. And finally, they each post their installation instructions online.
These are some of the considerations that immediately come to mind upon first glance at Autoflex.