I ran my truck pretty hard since buying at 40K miles (99 F250). At 55K the turbo was rebuilt and shortly after a 78hp Diablo Sport chip was installed. Being young and not so smart at the time the work truck was beat on daily and it wasn't uncommon to find me burning out with 1K+ lbs of weight in the box or while pulling a trailer. Not to my surprise at 83K miles the second gear synchro was shot. 1,000 miles later a $2,000 rebuilt Ford unit was installed in my shop.
At 100K miles the in line tranny filter was finally installed (still original). At 123K miles the torque convertor failed due to driving up a mountain in first gear resulting in an overheated tranny causing 9+ quarts to leak up the mountain. It was a $960 dollar repair but better than another tranny replacement. At 160K the tranny fluid was flushed and at 185K miles a large tranny cooler was installed with triple guages.
Now at 215K miles the $2,000 tranny is running stronger than ever. The truck is used daily for work, pushes snow and pulls up to 20K lbs a few times a year but averages about 20 tows a year of 12-17K lbs.
My wifes ride the diesel Excursion has 155K miles on the original tranny but doesn't get worked that hard.