"Generally", if you are towing at your peak torque, 2000 rpm, you should get your best mileage. Example, at 2000 rpm "empty" in overdrive (6th) gear, my speedometer is at 71 mph. If I were to only use the truck to pull a 5er or trailer, then I would change my gear ratio so as to be at the legal speed limit while pulling and be at 2000 rpm.
In your situation, at 2000 rpm, 38 inch tires, 3.73 differential, a speed of 61.12 mph is obtained while in direct drive (not overdrive). That looks pretty good to me.