I've experimented with Diesel Kleen on my 2010 6.4 over several thousand miles with and without it, and then again to confirm repeatability. In conclusion, I do not see/feel any benefit in terms of performance or hand-calculated mileage gains. If anything, idle seems quieter.
I always use name-brand fuel from Chevron, Shell, and more recently, Costco, so I'm thinking supplemental additives might help for fuel that doesn't already come loaded with additives. Pay a bit extra for good fuel to avoid the need for additional additives.
135K on the rig as of the moment and so far no issues not having run any additives for many 10's of K miles. Mpg still sucks exactly the same as when it was new. LOL.