I would think so. If most people with 4X4s can clear 35s with a 4", you should be able to clear with a 6" on a 2wd. Isn't there only a couple inches difference in height between a 2wd and a 4wd?
I've been looking into the whole lift thing and found that you only need 4" to clear 35/12.50's. You do, however, need to get proper back spacing. You can stuff 37's with 6".